Blar i forfatter "Tooze, Sharon A"

Viser treff 1-6 av 6

    • ATG9A protects the plasma membrane from programmed and incidental permeabilization. 

      Claude-Taupin, Aurore; Jia, Jingyue; Bhujabal, Zambarlal; Garfa-Traore, Meriem; Kumar, Suresh; da Silva, Gustavo Peixoto Duarte; Javed, Ruheena; Gu, Yuexi; Allers, Lee; Peters, Ryan; Wang, Fulong; da Costa, Luciana Jesus; Pallikkuth, Sandeep; Lidke, Keith A; Mauthe, Mario; Verlhac, Pauline; Uchiyama, Yasuo; Salemi, Michelle; Phinney, Brett; Tooze, Sharon A; Mari, Muriel C.; Johansen, Terje; Reggiori, Fulvio; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)
      The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation ...

    • Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease 

      Mercado, Nicolas; Colley, Thomas; Baker, Jonathan R.; Vuppussetty, Chaitanya; Kono, Yuta; Clarke, Colin; Tooze, Sharon A; Johansen, Terje; Barnes, Peter J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress‐induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective ...

    • Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs 

      Birgisdottir, Åsa Birna; Mouilleron, Stephane; Bhujabal, Zambarlal; Wirth, Martina; Sjøttem, Eva; Evjen, Gry; Zhang, Wenxin; Lee, Rebecca; O'Reilly, Nicola; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-04)
      Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1). The latter contains PIK3C3/VPS34, PIK3R4/VPS15, BECN1/Beclin 1 ...

    • Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity 

      Wirth, Martina; Mouilleron, Stephane; Zhang, Wenxin; Abudu, Yakubu Princely; Jain, Ashish; Olsvik, Hallvard Lauritz; Bruun, Jack-Ansgar; Razi, Minoo; Jefferies, Harold B.J.; Lee, Rebecca; Joshi, Dhira; O'Reilly, Nicola; Johansen, Terje; Tooze, Sharon A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      <p>Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration. Autophagy-related 8 (ATG8) proteins play a central role in autophagosome formation and selective delivery of cytoplasmic cargo to lysosomes by recruiting autophagy adaptors and receptors. The LC3-interacting region (LIR) docking site (LDS) of ...

    • SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components 

      Abudu, Yakubu Princely; Shrestha, Birendra Kumar; Zhang, Wenxin; Palara, Anthimi; Brenne, Hanne Britt; Larsen, Kenneth Bowitz; Wolfson, Deanna; Dumitriu, Gianina; Øie, Cristina Ionica; Ahluwalia, Balpreet Singh; Levy, Gahl; Behrends, Christian; Tooze, Sharon A; Mouilleron, Stephane; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Mitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the ...

    • SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy 

      Abudu, Yakubu Princely; Mouilleron, Stephane; Tooze, Sharon A; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
      Mitophagy, the clearance of surplus or damaged mitochondria or mitochondrial parts by autophagy, is important for maintenance of cellular homeostasis. Whereas knowledge on programmed and stress-induced mitophagy is increasing, much less is known about mechanisms of basal mitophagy. Recently, we identified SAMM50 (SAMM50 sorting and assembly machinery component) as a receptor for piecemeal degradation ...